Moeen Ali made the breakthrough at Twenty20 cricket for England but finished on the losing side as the West Indies triumphed by five wickets to take a series-clinching 2-0 lead at the Kensington Oval.
Moeen had played in the three one-day internationals in Antigua, scoring 44, 10 and 55 in the opening role and picking up a wicket in each game.
The Worcestershire all-rounder missed out on selection for the opening Twenty20 encounter but was recalled for the second match to bat at number three.
He made five before he was trapped lbw by a slower delivery from paceman Krishmar Santokie who finished with 4-21.
Moeen had flicked the same bowler for four off his legs the delivery prior to his dismissal.
England recovered from 26-3 to 152-7 in their 20 overs thanks mainly to Jos Buttler's 67 off 43 balls.
Moeen was not given the opportunity to bowl when the West Indies replied and reached their target with seven balls to spare.
He will be hoping for another opportunity to stake a claim to be part of the England side in the ICC Twenty20 in Bangladesh in the final match of the series at the same venue on Thursday.