Worcestershire were forced to follow despite determined resistance from their lower order on day three of the Specsavers County Championship clash with Derbyshire at the 3aaa County Ground.
Derbyshire declared at lunch on 467-5 from 127 overs with Jack Shantry claiming his 250th first class wicket in dismissing Billy Godleman for a career best 204.
Worcestershire were 18-5 at one stage in their first innings but useful knocks from Tom Kohler-Cadmore, Ben Cox, Matt Henry and Ed Barnard enabled them to reach 164 all out – 303 in arrears.
Unsurprisingly, the visitors were asked to bat again and closed on 24-1.
They will now be looking to bat through the final day and claim the five points available for securing a draw.
Worcestershire had picked up two wickets during the morning session after Derbyshire had resumed on 319-3 from 96 overs with Godleman unbeaten on 157 and Neil Broom 28.
Godleman reached his first double century off 325 balls with 25 fours and three sixes.
He was finally dismissed for 204, caught by Kohler-Cadmore off a top edged pull from the bowling of Shantry after adding 155 in 35.3 overs with Broom.
It was the highest score by a Derbyshire player against Worcestershire, passing the unbeaten 200 by Thomas Worthington at Chesterfield in 1933.
Godleman's dismissal also gave Shantry the 250th first class wicket of his career in his 82nd match at an average of 28.16.
Shantry then held onto a catch on the boundary to dismiss Broom for 93 off the bowling of Brett D'Oliveira.
He faced 131 balls and struck 11 fours, Derbyshire finally declared at lunch on 467-5 from 127 overs.
Joe Leach finished with 2-90, Shantry 2-102 and D'Oliveira 1-57.
Worcestershire initially ran into trouble when they launched their reply against Ben Cotton with D'Oliveira (4) caught at short leg, Joe Clarke falling at third slip and Daryl Mitchell (2) bowled after shouldering arms.
Tony Palladino then bowled Alexei Kervezee (0) and had Ross Whiteley (2) taken at first slip with the total on 18-5.
Kohler-Cadmore and Cox launched a positive counter-attack and brought up their half century stand in 11 overs.
They added 66 in total before Cox, having made 40 off 47 balls with seven fours, was trapped lbw by Palladino.
Leach (5) was bowled by Will Davis and Kohler-Cadmore's resistance ended after making 29 from 70 balls with six fours when he departed in the same manner.
Barnard and Henry saw Worcestershire through to 102-8 by tea.
The pair put on 53 in 19 overs before Henry (31) was caught behind off Cotton.
Barnard added another 20 for the last wicket with Shantry (12 not out) before he became a victim of Chesney Hughes on 28.
Cotton finished with 4-28 and Palladino 4-32.
When Worcestershire followed on, Wayne Madsen held onto a fine catch at gulley to dismiss Mitchell (6) off Cotton.