Worcestershire skipper Daryl Mitchell won the toss and put Oxford MCCU into bat after winning the toss in his side's opening first class fixture of the campaign at The Parks.
Ben Cox returned behind the stumps after skippering the second eleven in their exciting drawn game with Somerset Seconds at New Road.
All-rounder Gareth Andrew was given another opportunity to build up his match fitness after his return from a lumbar pedicle fracture in his back.
He impressed when taking the new ball in the two-day clash with visiting Gloucestershire last week.
Brett D'Oliveira was chosen as the front-line spinner and Shaaiq Choudhry is side-lined for a month with a side strain.
Oxford MCCU SD Weller, SG Leach, LC Paternott, LM Sabin, JN McIver, JO Grundy, EJ Ellis, HCD Hughes, LA Webb, MB Lake, MJL Kidd.
Worcestershire DKH Mitchell, RK Oliver, T Kohler-Cadmore, TC Fell, APR Gidman, AN Kervezee, OB Cox, GM Andrew, BL D'Oliveira, JD Shantry, CAJ Morris.